Ammonia → 1-(4-Methoxybenzo[d]thiazol-2-yl)urea

HRID 1060289ノート

反応式

HRID 1060289 の反応式
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[C:5]=2[N:6]=1.[NH2:13][C:14](N)=[O:15].N>O>[CH3:12][O:11][C:7]1[C:5]2[N:6]=[C:2]([NH:1][C:14]([NH2:13])=[O:15])[S:3][C:4]=2[CH:10]=[CH:9][CH:8]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 1176UreaHCID 216224-Methoxy-2-aminobenzothiazole

生成物 1

HCID 222830361-(4-Methoxybenzo[d]thiazol-2-yl)urea

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 2-amino-4-methoxy-benzothiazole (330 mg, 1.83 mmol) and urea (1.1 g, 1.83 mmol) were heated together for 1 h at 170° C., with evolution of ammonia. After allowing to cool to r.t., water (10 ml) was added and the mixture was vigorously stirred. The solid was then filtered, washed with water (10 ml) followed by ethanol (10 ml) and dried at 60° C. under vaccum (0.05 mmHg). The title product was afforded as an off-white solid (300 mg, 73% yield), MS: m/e=223 (M+).

後処理

  1. filtrationThe solid was then filtered
  2. washwashed with water (10 ml)
  3. customdried at 60° C. under vaccum (0.05 mmHg)

出典と根拠

ORDレコード
ord-5e47205b13d14e91a5d9d364e4b842d7
出典データセット
uspto-grants-2003_02
特許番号
US06521754B2

反応ノート

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