Potassium Hydroxide → Sodium 4-(6-hydroxyhexyl)oxybenzenesulfonate

HRID 10605ノート

反応式

HRID 10605 の反応式
[Na+:1].[OH:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([O-:12])(=[O:11])=[O:10])=[CH:5][CH:4]=1.[OH-].[K+].Br[CH:16]([OH:22])[CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]>C(O)C>[OH:22][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([O-:12])(=[O:10])=[O:11])=[CH:5][CH:4]=1.[Na+:1]

参加物

5

反応物 3

HCID 14797Potassium HydroxideHCID 4379756Sodium 4-hydroxybenzenesulfonateHCID 21981760Bromohexanol

生成物 1

HCID 23717227Sodium 4-(6-hydroxyhexyl)oxybenzenesulfonate収率 98.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Into a three-necked round-bottom flask equipped with a magnetic stirring bar and a reflux condenser were added 4-hydroxybenzenesulfonicacid sodium salt (30.0 grams (g), 0.13 mol), potassium hydroxide (9.0 g, 0.16 mol) and distilled water (60 milliliter (ml)). 1-Bromohexanol (23.16 g, 0.13 mol) dissolved in ethanol (50 ml) was added drop wise into the reaction mixture at room temperature. The reaction mixture was refluxed for 24 hours and then cooled to room temperature. The precipitated product was filtered and washed with chloroform to remove excess of 1-bromohexanol. The product was dried under vacuum at 70° C. for 12 hours to provide 38.06 g of sodium 4-(6-hydroxyhexyl)oxybenzenesulfonate (92% yield).

後処理

  1. customInto a three-necked round-bottom flask equipped with a magnetic stirring bar and a reflux condenser
  2. distillationdistilled water (60 milliliter (ml))
  3. additionwas added drop wise into the reaction mixture at room temperature
  4. temperatureThe reaction mixture was refluxed for 24 hours
  5. filtrationThe precipitated product was filtered
  6. washwashed with chloroform
  7. customto remove excess of 1-bromohexanol
  8. customThe product was dried under vacuum at 70° C. for 12 hours

出典と根拠

ORDレコード
ord-62574a4f57594484b87becc8b7f760e8
出典データセット
uspto-grants-2006_08
特許番号
US07094861B2

反応ノート

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