3-Pentanamine → (2R,3R,4S,5S)-4-(Benzoyloxy)-5-[(ethylamino)carbonyl]-2-{6-[(1-ethylpropyl)amino]-2-iodo-9H-purin-9-yl}tetrahydro-3-furanyl benzoate

反応式

[C:1]([O:9][C@@H:10]1[C@H:14]([O:15][C:16](=[O:23])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C@@H:13]([C:24]([NH:26][CH2:27][CH3:28])=[O:25])[O:12][C@H:11]1[N:29]1[CH:37]=[N:36][C:35]2[C:30]1=[N:31][C:32]([I:39])=[N:33][C:34]=2Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:40]([CH:42]([NH2:45])[CH2:43][CH3:44])[CH3:41]>>[C:1]([O:9][C@@H:10]1[C@H:14]([O:15][C:16](=[O:23])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C@@H:13]([C:24]([NH:26][CH2:27][CH3:28])=[O:25])[O:12][C@H:11]1[N:29]1[CH:37]=[N:36][C:35]2[C:30]1=[N:31][C:32]([I:39])=[N:33][C:34]=2[NH:45][CH:42]([CH2:43][CH3:44])[CH2:40][CH3:41])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

反応物 2

HCID 120193-Pentanamine

HCID 10189909(2R,3R,4S,5S)-4-(benzoyloxy)-2-(6-chloro-2-iodo-9H-purin-9-yl)-5-[(ethylamino)carbonyl]tetrahydro-3-furanyl benzoate

生成物 1

HCID 10146825(2R,3R,4S,5S)-4-(Benzoyloxy)-5-[(ethylamino)carbonyl]-2-{6-[(1-ethylpropyl)amino]-2-iodo-9H-purin-9-yl}tetrahydro-3-furanyl benzoate

実験手順

Prepared from ((2R,3R,4S,5S)-4-(benzoyloxy)-2-(6-chloro-2-iodo-9H-purin-9-yl)-5-[(ethylamino)carbonyl]-tetrahydro-3-furanyl benzoate (Preparation 19) and 1-ethylpropylamine by the same method as Preparation 20. The title compound was obtained as a yellow foam.

後処理

customas Preparation 20

出典と根拠

ORDレコード: ord-81b6a61d3c8649c184b748f6670258fd
出典データセット: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06525032B2

反応ノート

読み込み中…