Acetone → HCID 22711430、化合物

HRID 1061008ノート

反応式

HRID 1061008 の反応式
Cl.C(O)C.CC(C)=O.C(OC([N:16]1[CH2:21][CH2:20][N:19]([C:22]([C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N+:31]=3[O-:36])=[CH:26][CH:25]=2)=[O:23])[CH2:18][CH2:17]1)=O)(C)(C)C>ClCCl>[N:19]1([C:22]([C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N+:31]=3[O-:36])=[CH:26][CH:25]=2)=[O:23])[CH2:20][CH2:21][NH:16][CH2:17][CH2:18]1

参加物

5

反応物 3

HCID 180AcetoneHCID 21887872Ethanol hydrochlorideHCID 69700183HCID 69700183、化合物

生成物 1

HCID 22711430HCID 22711430、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In dichloromethane (2.5 ml), 2-[4-[[4-(tert-butoxycarbonyl)piperazin-1-yl]carbonyl]phenyl]pyridine N-oxide was dissolved. To the resulting solution, a saturated solution of ethanol hydrochloride (2.5 ml) was added, followed by stirring at room temperature for 1 hour. After the solvent was distilled off under reduced pressure, water was added to the residue, whereby an aqueous solution was obtained. Acetone was added to the aqueous solution until the solution became turbid. The precipitate was collected by filtration and washed with acetone, whereby the title compound (274 mg, 81%) was obtained.

後処理

  1. distillationAfter the solvent was distilled off under reduced pressure, water
  2. additionwas added to the residue, whereby an aqueous solution
  3. customwas obtained
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with acetone, whereby the title compound (274 mg, 81%)
  6. customwas obtained

出典と根拠

ORDレコード
ord-b5f09648e6234f70b2646c5849bad27f
出典データセット
uspto-grants-2003_02
特許番号
US06525042B1

反応ノート

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