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(Butylamino)acetonitrile → N-Butyl-N-(cyanomethyl)-4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (Butylamino)acetonitrile | HCID 76373 | — |
| 反応物 | 4-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-benzoic acid | HCID 15948425 | — |
| 生成物 | N-Butyl-N-(cyanomethyl)-4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)benzamide | HCID 22220389 | — |
反応手順
The title compound was prepared from 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-benzoic acid (which was obtained in Example 150) (0.37 g, 1.4 mmol) and (n-butylamino)acetonitrile (0.48 g, 4.2 mmol) according to the procedure shown for Example 154 to give 0.52 g of an amber gum; MS (ES) m/z: 358.3 (MH+); HRMS (ES) Calcd. for C20H28N3O3 (MH+): 358.2125, Found: 358.2120.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06525202B2 |
| 出典データセット | uspto-grants-2003_02 |
| ORD ID | ord-a341565257bf478d98daa966afe87904 |
| 出典メモ | uspto-grants-2003_02 |