4-chloro-3-nitro-N-(pyridin-3-ylmethyl)benzenesulfonamide → 4-Amino-3-nitro-N-(3-pyridinylmethyl)benzenesulfonamide

HRID 1061549ノート

反応式

HRID 1061549 の反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:19]([O-:21])=[O:20].[NH3:22].CO>>[NH2:22][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:19]([O-:21])=[O:20]

参加物

3

反応物 2

HCID 28583054-chloro-3-nitro-N-(pyridin-3-ylmethyl)benzenesulfonamideHCID 21705897Ammonia methanol

生成物 1

HCID 222851684-Amino-3-nitro-N-(3-pyridinylmethyl)benzenesulfonamide

反応条件

温度
100 °C

実験手順

Into a saturated ammonia-methanol solution (60 ml) was added 4-chloro-3-nitro-N-(pyridin-3-ylmethyl)benzenesulfonamide (2.77 g), followed by about 2 days of heating at 100° C. in a sealed tube. After the reaction, the solvent was evaporated under reduced pressure and the formed yellow crystals were collected by filtration and dried to obtain 4-amino-3-nitro-N-(pyridin-3-ylmethyl)benzenesulfonamide (2.51 g). Hereinafter, the compound of Reference Examples 26 was obtained similarly.

後処理

  1. customAfter the reaction
  2. customthe solvent was evaporated under reduced pressure
  3. filtrationthe formed yellow crystals were collected by filtration
  4. customdried

出典と根拠

ORDレコード
ord-9f9472e3325a4e56940e70a7170ae712
出典データセット
uspto-grants-2005_11
特許番号
US06960591B2

反応ノート

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