Ammonia → (2RS,3S)-3-Amino-2-hydroxy-4-phenylbutyramide

HRID 1061655ノート

反応式

HRID 1061655 の反応式
[NH2:1][C@@H:2]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:3]([OH:10])[C:4](OC(C)C)=[O:5].[NH3:18]>CO>[NH2:1][C@@H:2]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:3]([OH:10])[C:4]([NH2:18])=[O:5]

参加物

4

反応物 2

HCID 222AmmoniaHCID 11736536isopropyl (2RS,3S)-3-amino-2-hydroxy-4-phenylbutyrate

生成物 1

HCID 57310726(2RS,3S)-3-Amino-2-hydroxy-4-phenylbutyramide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of isopropyl (2RS,3S)-3-amino-2-hydroxy-4-phenylbutyrate (200 mg, Reference compound No. 4-1) in methanol (3 ml) is saturated with an ammonia gas, and the solution is sealed and stirred overnight. The reaction solution is concentrated under reduced pressure to give the titled reference compound (162 mg).

後処理

  1. customthe solution is sealed
  2. concentrationThe reaction solution is concentrated under reduced pressure

出典と根拠

ORDレコード
ord-8aa7d5ce399044a19095ca39e8c1e607
出典データセット
uspto-grants-2005_11
特許番号
US06960575B2

反応ノート

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