2-Chloro-4-(2-fluoro-5-nitrophenyl)pyrimidine → 3-(2-Chloropyrimidin-4-yl)-4-fluorophenylamine
反応式
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[C:12]([N+:14]([O-])=O)[CH:11]=[CH:10][C:9]=2[F:17])[CH:5]=[CH:4][N:3]=1>C(O)C>[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[C:12]([NH2:14])[CH:11]=[CH:10][C:9]=2[F:17])[CH:5]=[CH:4][N:3]=1参加物
3
実験手順
A solution of 2-chloro-4-(2-fluoro-5-nitrophenyl)pyrimidine (800 mg, 3.2 mmol) in ethanol (300 mL) was reduced under 40 p.s.i. hydrogen with platinum(IV) oxide (100 mg) for 30 minutes then filtered to give a solution of 3-(2-chloro-pyrimidin-4-yl)-4-fluorophenylamine: m/z (ES+) 224 (M++H).
後処理
- filtrationhydrogen with platinum(IV) oxide (100 mg) for 30 minutes then filtered
出典と根拠
- ORDレコード
- ord-3fec487d64514a7bbd2d1701dfe3d3c0
- 出典データセット
- uspto-grants-2005_11
- 特許番号
- US06960598B2
反応ノート
読み込み中…