Phenol → 2-Hydroxy-9H-thioxanthen-9-one
反応式
C(C[O:5][C:6]1[CH:19]=[CH:18][C:17]2[S:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9](=[O:20])[C:8]=2[CH:7]=1)(O)=O.C1(O)C=CC=CC=1.C(O)(=O)C1C=CC=CC=1SSC1C=CC=CC=1C(O)=O>>[OH:5][C:6]1[CH:19]=[CH:18][C:17]2[S:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9](=[O:20])[C:8]=2[CH:7]=1参加物
4
実験手順
An example of a conventional synthetic route to 2-carboxymethoxythioxanthone involves three stages. Firstly, phenol is reacted with dithiobisbenzoic acid to produce 2-hydroxythioxanthone in a 60% yield. Secondly, the 2-hydroxythioxanthone is reacted with ethyl bromoacetate to produce the ethyl ester of 2-carboxymethoxythioxanthone in 75% yield. Thirdly, the ester is hydrolysed by acidification to produce the desired product in 90% yield. These three stages form an inefficient and time-consuming process to provide a product that is a dark colour, contains impurities and by-products and is produced with only an overall yield of 40% from the starting material.
出典と根拠
- ORDレコード
- ord-2cfa9d7a2cba40beb6133a1869117346
- 出典データセット
- uspto-grants-2005_11
- 特許番号
- US06960668B2
反応ノート
読み込み中…