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Thionyl Chloride → 2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazole-4-carbonyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazole-4-carboxylic acid | HCID 21868804 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazole-4-carbonyl chloride | HCID 22285374 | — |
反応手順
Thionyl chloride (0.66 mL, 9 mmol) was added to a solution of 2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazole-4-carboxylic acid (1 g, 3 mmol) in toluene (10 mL). The mixture was refluxed under argon for 1.5 h and concentrated to provide 2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazole-4-carbonyl chloride, which was used in the next step without purification. 1H NMR (300 MHz, CD2Cl2) δ 8.40 (s, 1H), 7.69-7.09 (m, 8H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06960601B2 |
| 出典データセット | uspto-grants-2005_11 |
| ORD ID | ord-381ddc6bcae14776a03dee8b23f61bb1 |
| 出典メモ | uspto-grants-2005_11 |