Water → HCID 11315915、化合物

HRID 1062623ノート

反応式

HRID 1062623 の反応式
[CH3:1][C:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:19])[CH2:12][C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[CH:7][CH:6]=1)([CH3:4])[CH3:3].[Br:20]Br.O>C(O)(=O)C>[BrH:20].[Br:20][CH:12]([C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)[C:11]([C:8]1[CH:9]=[CH:10][C:5]([C:2]([CH3:1])([CH3:3])[CH3:4])=[CH:6][CH:7]=1)=[O:19]

参加物

5

反応物 3

HCID 962WaterHCID 24408BromineHCID 104674521-[4-(1,1-DIMETHYLETHYL)PHENYL]-2-(4-PYRIDYL)ETHANONE

生成物 1

HCID 11315915HCID 11315915、化合物収率 119.2%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
80 °C

実験手順

1-[4-(1,1-Dimethylethyl)phenyl]-2-(4-pyridyl)ethanone (10 g, 39 mmol) was dissolved in acetic acid (40 mL) and bromine (2.0 mL, 39 mmol) was added. The mixture was stirred at 80° C. for 3 h. The reaction mixture was cooled with iced water and the precipitated crude crystals were collected by filtration. The crude crystals were washed with ethyl acetate to give the title compound (9.6 g, yield 81%).

後処理

  1. customthe precipitated crude crystals
  2. filtrationwere collected by filtration
  3. washThe crude crystals were washed with ethyl acetate

出典と根拠

ORDレコード
ord-f4bd80bc9c6b4b319f78dc9c59c4b919
出典データセット
uspto-grants-2005_11
特許番号
US06962933B1

反応ノート

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