Ethyl Acetate → 2-Bromo-1-(3,5-dimethylphenyl)-2-(4-pyridyl)ethanone hydrocbromide

HRID 1062624ノート

反応式

HRID 1062624 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1.[Br:18]Br.C(OCC)(=O)C>C(O)(=O)C>[BrH:18].[Br:18][CH:10]([C:11]1[CH:12]=[CH:13][N:14]=[CH:15][CH:16]=1)[C:9]([C:4]1[CH:5]=[C:6]([CH3:8])[CH:7]=[C:2]([CH3:1])[CH:3]=1)=[O:17]

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 24408BromineHCID 222822971-(3,5-Dimethylphenyl)-2-(4-pyridyl)ethanone

生成物 1

HCID 222823612-Bromo-1-(3,5-dimethylphenyl)-2-(4-pyridyl)ethanone hydrocbromide収率 268.1%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
80 °C

実験手順

1-(3,5-Dimethylphenyl)-2-(4-pyridyl)ethanone (7.0 g, 31 mmol) was dissolved in acetic acid (35 mL) and bromine (1.6 mL, 31 mmol) was added. The mixture was stirred at 80° C. for 3 h. Ethyl acetate was added to the residue and the precipitated crude crystals were collected by filtration. The crude crystals were washed with ethyl acetate to give the title compound (16 g, yield 96%).

後処理

  1. customthe precipitated crude crystals
  2. filtrationwere collected by filtration
  3. washThe crude crystals were washed with ethyl acetate

出典と根拠

ORDレコード
ord-6f7af2f2688c4bf982c5924a2bc5786b
出典データセット
uspto-grants-2005_11
特許番号
US06962933B1

反応ノート

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