Sodium Bicarbonate → HCID 22282317、化合物

HRID 1062649

反応式

HRID 1062649 の反応式
Br.Br[CH:3]([C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)[C:4]([C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)=O.C[C:20]1[CH:28]=[CH:27][C:23]([C:24]([NH2:26])=[S:25])=[CH:22][CH:21]=1.C(=O)([O-])O.[Na+]>CN(C)C=O>[F:12][C:9]1[CH:10]=[CH:11][C:6]([C:4]2[N:26]=[C:24]([C:23]3[CH:27]=[CH:28][CH:20]=[CH:21][CH:22]=3)[S:25][C:3]=2[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[CH:7][CH:8]=1

参加物

5

反応物 3

HCID 516892Sodium BicarbonateHCID 7372094-MethylbenzenecarbothioamideHCID 11164724HCID 11164724、化合物

生成物 1

HCID 22282317HCID 22282317、化合物収率 19.8%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 2-bromo-1-(4-fluorophenyl)-2-(4-pyridyl)ethanone hydrobromide (1.6 g, 4.1 mmol) and thiobenzamide (0.57 g, 4.2 mmol) in N,N-dimethylformamide (5 mL) was stirred at room temperature for 14 h. To the reaction mixture was poured aqueous sodium hydrogencarbonate solution and the precipitated solid was collected by filtration. The obtained solid was washed with water and dried. The crude crystals were recrystallized from ethyl acetate to give the title compound (0.27 g, yield 19%).

後処理

  1. filtrationthe precipitated solid was collected by filtration
  2. washThe obtained solid was washed with water
  3. customdried
  4. customThe crude crystals were recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-f7dda7cc1d4043bb968d24d953958261
出典データセット
uspto-grants-2005_11
特許番号
US06962933B1

関連ノート

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