4-(t-Butoxycarbonyl)amino-2'-methylsulfonyl-[1,1']biphenyl → 4-(2-Methylsulfonylphenyl)aniline

HRID 1062656ノート

反応式

HRID 1062656 の反応式
C(OC([NH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[S:21]([CH3:24])(=[O:23])=[O:22])=[CH:11][CH:10]=1)=O)(C)(C)C>Cl.O1CCOCC1>[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[S:21]([CH3:24])(=[O:23])=[O:22])=[CH:11][CH:10]=1

参加物

4

反応物 1

HCID 222825004-(t-Butoxycarbonyl)amino-2'-methylsulfonyl-[1,1']biphenyl

生成物 1

HCID 108005164-(2-Methylsulfonylphenyl)aniline収率 114.8%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 312751,4-Dioxane溶媒

実験手順

4-(t-butoxycarbonyl)amino-2′-methylsulfonyl-[1,1′]biphenyl (4.6 g, 13 mmol), was suspended in 100 mL of 4M HCl in dioxane and stirred 2.5 days. The resulting mixture was filtered and the cake rinsed with Et2O to yield a tan solid (3.69 g, 98%). 1H NMR (DMSO-d6) δ: 8.04 (d, 1H), 7.71 (t, 1H), 7.61 (t, 1H), 7.31 (m, 3H), 7.06 (m, 2H), 2.79 (s, 3H).

後処理

  1. filtrationThe resulting mixture was filtered
  2. washthe cake rinsed with Et2O

出典と根拠

ORDレコード
ord-76430c068f6d4402a0da3177cbdce4f2
出典データセット
uspto-grants-2005_11
特許番号
US06962935B2

反応ノート

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