Acetic Acid → 4-Methoxy-1H-pyrazolo[3,4-d]pyrimidin-6-amine
反応式
Cl[C:2]1[N:7]=[C:6]([NH2:8])[N:5]=[C:4]2[NH:9][N:10]=[CH:11][C:3]=12.[C:12](O)(=[O:14])C>C[O-].[Na+]>[CH3:12][O:14][C:2]1[N:7]=[C:6]([NH2:8])[N:5]=[C:4]2[NH:9][N:10]=[CH:11][C:3]=12参加物
4
実験手順
Compound 3 (70.4 g, 0.416 mol) was refluxed in methanolic sodium methoxide solution (25 g sodium dissolved in 1 L methanol) for 2 h. The reaction mixture was cooled to room temperature and neutralized by addition of acetic acid (75 ml). The mixture was evaporated to dryness and the solid was triturated in 600 ml of water, filtered and dried to provide 67.5 g (99% yield) of 4-methoxy-6-aminopyrazolo[3,4-d]pyrimidine (4).
後処理
- customThe mixture was evaporated to dryness
- customthe solid was triturated in 600 ml of water
- filtrationfiltered
- customdried
出典と根拠
- ORDレコード
- ord-3142ad87d75e4854845801b740436dbc
- 出典データセット
- uspto-grants-2005_11
- 特許番号
- US06962991B2
反応ノート
読み込み中…