Triethylamine → HCID 178425008、化合物

HRID 1063104

反応式

HRID 1063104 の反応式
[C:1]([CH2:3][C:4]([NH2:6])=[S:5])#[N:2].[CH3:7][CH:8]([CH3:16])[CH2:9][C:10](=O)[CH2:11][C:12](=O)[CH3:13].C(N(CC)CC)C>CCO>[CH2:9]([C:10]1[CH:11]=[C:12]([CH3:13])[C:3]([C:1]#[N:2])=[C:4]([SH:5])[N:6]=1)[CH:8]([CH3:16])[CH3:7]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 763542,4-Heptanedione, 6-methyl-HCID 14162772-Cyanoethanethioamide

生成物 1

HCID 178425008HCID 178425008、化合物収率 61.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
50 °C

実験手順

To a stirred solution of cyanothioacetamide (2.20 g, 22 mmol) and 6-methyl-2,4-heptanedione (3.12 g, 22 mmol) in anhydrous EtOH (40 mL) was added triethylamine (0.4 mL) and the reaction was heated at 50° C. for 1 h before it was allowed to cool to room temperature. Filtration and washing of the precipitates with EtOH gave 6-isobutyl-2-mercapto-4-methylnicotinonitrile as a yellow solid (2.8 g, 61%).

後処理

  1. temperatureto cool to room temperature
  2. filtrationFiltration
  3. washwashing of the
  4. customprecipitates with EtOH

出典と根拠

ORDレコード
ord-e596cdfa137c4fe3821a20fb1f6b005e
出典データセット
uspto-grants-2005_11
特許番号
US06964956B2

関連ノート

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