Hydrochloric Acid → (S)-4-(pyrrolidin-2-ylmethyl)morpholine
反応式
Cl.C(OC([N:9]1[CH2:13][CH2:12][CH2:11][C@H:10]1[CH2:14][N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)=O)(C)(C)C>CO>[NH:9]1[CH2:13][CH2:12][CH2:11][C@H:10]1[CH2:14][N:15]1[CH2:16][CH2:17][O:18][CH2:19][CH2:20]1参加物
4
実験手順
HCl (g) was introduced into a solution of (S)-2-morpholin-4-ylmethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (400 mg, 1.47 mmol) in MeOH. After 5 min., the reaction solution was concentrated under reduced pressure to give a white solid (300 mg, 99%). MS: 170.9 (MH+); HPLC Rf: n.d.; HPLC purity: n.d.
後処理
- concentrationthe reaction solution was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-e83fdfc8d48d44069425d5f57c394ac0
- 出典データセット
- uspto-grants-2005_11
- 特許番号
- US06964961B2
反応ノート
読み込み中…