3-chloro-2-methyl-1H-indol-5-amine → (3S)-[7-(3-Chloro-2-methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-(3-methoxy-pyrrolidin-1-yl)-methanone

HRID 1063224ノート

反応式

HRID 1063224 の反応式
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([C:11]([N:13]3[CH2:17][CH2:16][C@H:15]([O:18][CH3:19])[CH2:14]3)=[O:12])[S:10][C:3]=12.[Cl:20][C:21]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([NH2:30])[CH:28]=2)[NH:23][C:22]=1[CH3:31]>>[Cl:20][C:21]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([NH:30][C:2]3[CH:7]=[CH:6][N:5]=[C:4]4[CH:8]=[C:9]([C:11]([N:13]5[CH2:17][CH2:16][C@H:15]([O:18][CH3:19])[CH2:14]5)=[O:12])[S:10][C:3]=34)[CH:28]=2)[NH:23][C:22]=1[CH3:31]

参加物

3

反応物 2

HCID 222786213-chloro-2-methyl-1H-indol-5-amineHCID 23401173(3S)-(7-chloro-thieno[3,2-b]pyridin-2-yl)-(3-methoxy-pyrrolidin-1-yl)-methanone

生成物 1

HCID 23401170(3S)-[7-(3-Chloro-2-methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-(3-methoxy-pyrrolidin-1-yl)-methanone

実験手順

The title compound was prepared from (3S)-(7-chloro-thieno[3,2-b]pyridin-2-yl)-(3-methoxy-pyrrolidin-1-yl)-methanone and 3-chloro-2-methyl-1H-indol-5-ylamine by a procedure analogous to Example 103. MS: 441.2/443.2; 407.2(MH+); HPLC Rf: 4.96 min.; HPLC purity: 98%.

出典と根拠

ORDレコード
ord-c2b0437fa27a4dfb8a4a705ca23fddb0
出典データセット
uspto-grants-2005_11
特許番号
US06964961B2

反応ノート

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