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4-Acetylbenzoic Acid → 4-[3e-(2-Fluoro-4-thiophen-2-yl-phenyl)-acryloyl]-benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Acetylbenzoic Acid | HCID 11470 | — |
| 反応物 | 2-Fluoro-4-(thiophen-2-yl)benzaldehyde | HCID 16768608 | — |
| 生成物 | 4-[3e-(2-Fluoro-4-thiophen-2-yl-phenyl)-acryloyl]-benzoic acid | HCID 21041617 | 71% |
反応手順
The title compound was prepared by condensing 2-fluoro-4-thiophen-2-yl-benzaldehyde (Ex-30A) and 4-acetylbezoic acid in a similar manner as described in Ex-3. Yellow solid, 71% yield, m.p.>260° C. 1H-NMR (300 MHz, d6-DMSO): 8.19 (d, 2H, J=8.4 Hz), 8.12 (d, 1H, J=8 Hz), 8.06 (d, 2H, J=8 Hz), 7.95 (d, 1H, J=16 Hz), 7.80 (d, 1H, J=16 Hz), 7.71 (d, 1H, J=3.5 Hz), 7.62 (m, 2H), 7.56 (d, 1H, J=8 Hz), 7.15 (m, 1H). MS m/z=352 ([M]+, 100%). HRMS (EI) Calcd. for C20H13NO3S: 352.0569. Found: 352.0560.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07094801B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-8fc2ef8a042a46f58b067fa79d0eba07 |
| 出典メモ | uspto-grants-2006_08 |