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(Chloromethyl)cyclopropane → 2-Cyclopropylmethoxy-4-methoxy-5-thiophen-2-yl-benzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (Chloromethyl)cyclopropane | HCID 80013 | — |
| 反応物 | 2-Hydroxy-4-methoxy-5-thiophen-2-yl-benzaldehyde | HCID 11858998 | — |
| 生成物 | 2-Cyclopropylmethoxy-4-methoxy-5-thiophen-2-yl-benzaldehyde | HCID 21980974 | 18% |
反応手順
Ex-32A: 2-Cyclopropylmethoxy-4-methoxy-5-thiophen-2-yl-benzaldehyde was prepared in a similar manner as described in Ex-29C from 2-hydroxy-4-methoxy-5-thiophen-2-yl-benzaldehyde (Ex. 29B) and chloromethyl-cyclopropane, 18% yield. 1H-NMR (CDCl3) δ 10.41 (s, 1H), 8.24 (s, 1H), 7.43 (d, 1H), 7.29 (d, 1H), 7.06 (t, 1H), 6.45 (s, 1H), 3.95 (m, 5H), 1.31 (m, 1H), 0.68 (m, 2H), 0.40 (q, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07094801B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-2599c5c31bb8412fa660fff33be023f4 |
| 出典メモ | uspto-grants-2006_08 |