Acetyl chloride → 1-(4-(Methylthio)phenyl)ethan-1-one
反応式
[Al+3].[Cl-].[Cl-].[Cl-].[C:5]1([S:11][CH3:12])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[C:13](Cl)(=[O:15])[CH3:14]>C(Cl)Cl>[CH3:14][C:13]([C:8]1[CH:9]=[CH:10][C:5]([S:11][CH3:12])=[CH:6][CH:7]=1)=[O:15]参加物
5
反応条件
- 温度
- 0 °C
実験手順
123 g (0.92 mol) of AlCl3 are added with a spatula to a mixture of 100 g (0.8 mol) of thioanisole, 750 ml of CH2Cl2 and 63 ml (0.9 mol) of acetyl chloride, cooled to 0° C. beforehand, said addition being carried out so that the temperature does not exceed 10° C. The mixture is stirred for 1 h at room temperature, heated for 1 h at 40° C. and then poured into 800 ml of an ice/water mixture. The resulting mixture is separated and extracted with CH2Cl2. The organic phases are combined, washed with water and then dried over MgSO4 and concentrated to give 117.1 g of 4-(methylthio)acetophenone.
後処理
- additionaddition
- customdoes not exceed 10° C
- temperatureheated for 1 h at 40° C.
- customThe resulting mixture is separated
- extractionextracted with CH2Cl2
- washwashed with water
- dry with materialdried over MgSO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-b9e829672ee641d4912a1f2c034f3d35
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05723485
反応ノート
読み込み中…