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Hydrochloric Acid → 3-(Pyridin-4-yl)propanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 2-Acetamidodibenzothiophene | HCID 108627 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-(Pyridin-4-yl)propanoic acid | HCID 233243 | — |
反応手順
To a solution of ethyl 3-pyridin-4-ylpropanoate (Method 2; 103.1 g, 576 mmol) in water (400 ml) and ethanol (20 ml) at room temperature was added potassium hydroxide (60 g, 1600 mmol). After 18 hours hydrochloric acid (100 ml) was added to give a white solid. Yield 62.8 g (73%). NMR 8.38 (d, 2H), 7.21 (d, 2H), 2.70 (t, 2H), 2.52 (t, 2H); m/z 152.2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06967216B2 |
| 出典データセット | uspto-grants-2005_11 |
| ORD ID | ord-50519d7a41d24d5cb0afee1d39e0f1aa |
| 出典メモ | uspto-grants-2005_11 |