Hydrazine → 4-(3,4-Dichloro-phenyl)-5-pyridin-4-yl-pyrazolidin-3-one
反応式
C(OC(=O)[C:5](=[O:22])[C:6]([C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=1)=[CH:7][C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)C.[NH2:24][NH2:25]>C(O)C>[Cl:21][C:16]1[CH:15]=[C:14]([CH:6]2[CH:7]([C:8]3[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=3)[NH:25][NH:24][C:5]2=[O:22])[CH:19]=[CH:18][C:17]=1[Cl:20]参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a solution of 3-(3,4-Dichloro-phenyl)-2-oxo-4-pyridin-4-yl-but-3-enoic acid ethyl ester 11.4 g in ethyl alcohol 50 mL was added hydrazine 1.68 mL. The reaction was heated to 50° C. for 15 hours. All solvent was removed after under reduced pressure to afford the title compound 10.8 g as light yellow solid. MS (ES+): 308 (M+H)+.