Hydrochloric Acid → 5-Isopropyl-4-[methyl-(1H-pyrrolo[2,3-b]pyridin-5-yl)-amino]-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester

反応式

[CH3:1][NH:2][C:3]1[CH:4]=[C:5]2[CH:11]=[CH:10][NH:9][C:6]2=[N:7][CH:8]=1.[CH3:12][O:13][C:14]([C:16]1[C:17]([CH:26]([CH3:28])[CH3:27])=[C:18]2[N:23]([CH:24]=1)[N:22]=[CH:21][N:20]=[C:19]2Cl)=[O:15].Cl>>[CH3:12][O:13][C:14]([C:16]1[C:17]([CH:26]([CH3:28])[CH3:27])=[C:18]2[N:23]([CH:24]=1)[N:22]=[CH:21][N:20]=[C:19]2[N:2]([CH3:1])[C:3]1[CH:4]=[C:5]2[CH:11]=[CH:10][NH:9][C:6]2=[N:7][CH:8]=1)=[O:15]

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 22273610N-methyl-1H-pyrrolo[2,3-b]pyridin-5-amine

HCID 866038554-Chloro-5-isopropylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester

生成物 1

HCID 234035765-Isopropyl-4-[methyl-(1H-pyrrolo[2,3-b]pyridin-5-yl)-amino]-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester収率 25%

実験手順

The title compound was prepared in a manner similar to the preparation of Example 24 by using methyl-(1H-pyrrolo[2,3-b]pyridin-5-yl)-amine and 4-chloro-5-isopropylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester. (25% yield). LCMS; m/z 365 (M+H+). Monohydrochloride salt: 1H NMR (400 MHz, DMSO-d6) δ ppm 11.73 (1H, s), 8.22 (1H, s.), 8.00 (1H, s), 7.75 (1H, s), 7.50 (1H, s), 6.40 (1H, s.), 3.70 (3H, s), 3.26 (1H, m), 2.51 (3H, s), 0.54 (6H, d, J=7.3 Hz).