2-Acetylbenzoic acid → 2-[3E-(2,4-Dimethoxy-5-thiophen-2-yl-phenyl)-acryloyl]-benzoic acid

HRID 10645

反応式

HRID 10645 の反応式
[CH3:1][O:2][C:3]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([C:13]2[S:14][CH:15]=[CH:16][CH:17]=2)=[CH:7][C:4]=1[CH:5]=O.[C:18]([C:21]1[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=1[C:23]([OH:25])=[O:24])(=[O:20])[CH3:19]>>[CH3:1][O:2][C:3]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([C:13]2[S:14][CH:15]=[CH:16][CH:17]=2)=[CH:7][C:4]=1/[CH:5]=[CH:19]/[C:18]([C:21]1[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=1[C:23]([OH:25])=[O:24])=[O:20]

参加物

3

反応物 2

HCID 684742-Acetylbenzoic acidHCID 161161832,4-Dimethoxy-5-thien-2-ylbenzaldehyde

生成物 1

HCID 161157592-[3E-(2,4-Dimethoxy-5-thiophen-2-yl-phenyl)-acryloyl]-benzoic acid収率 47%

実験手順

The title compound was prepared by condensing 2,4-dimethoxy-5-(thiophen-2-yl)-benzaldehyde (Ex-6A) and 2-acetylbenzoic acid in a similar manner as described in Ex-3. Yellow solid, 47% yield, mp 196–198° C. 1H-NMR (DMSO-d6) δ 8.00 (s, 1H), 7.84 (d, 1H), 7.61 (m, 3H), 7.45 (m, 3H), 7.21 (d, 1H), 7.08 (t, 1H), 6.75 (s, 1H), 3.95 (s, 3H), 3.86 (s, 3H). MS m/z=394 ([M]+, 100%). Anal. calculated for C22H18O5S: C, 66.99; H, 4.60; S, 8.13. found C, 67.08; H, 4.17; S, 7.97.

出典と根拠

ORDレコード
ord-83a7ca9901c148adb3f76c7c46b13cc9
出典データセット
uspto-grants-2006_08
特許番号
US07094801B2

関連ノート

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