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Pyridine → 4-chloro-N-(2-methoxyphenyl)-3-nitrobenzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 2-Methoxyaniline | HCID 7000 | — |
| 反応物 | 4-Chloro-3-nitrobenzenesulfonamide | HCID 7324 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 4-chloro-N-(2-methoxyphenyl)-3-nitrobenzenesulfonamide | HCID 2887683 | — |
反応手順
4-Chloro-3-nitrobenzenesulfonamide (1.73 g, 6.78 mmol) was dissolved in CH2Cl2 (7.0 mL). o-Anisidine (1.00 g, 8.13 mmol) was added dropwise at room temperature, followed by a slow addition of pyridine (2.0 mL). After 16 h of continued stirring, the reaction mixture was diluted with EtOAc (50 mL) and washed with 1 M HCl (3×50 mL).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06969710B2 |
| 出典データセット | uspto-grants-2005_11 |
| ORD ID | ord-89a9e338246d4eeda76c9350ae94dcc3 |
| 出典メモ | uspto-grants-2005_11 |