3,8-Diazabicyclo[3.2.1]octane-8-carboxylate → 3-[(2-Oxo-2,3-dihydro-1H-indol-4ylcarbamoyl)-methyl]-3,8-diazabicyclo[3.2.1]octan-8-carboxylic acid, 1,1-dimethylethyl Ester
反応式
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:7]=1[CH2:8][C:9](=[O:15])[NH:10]2)=[O:4].[CH:16]12[N:23]([C:24]([O-:26])=[O:25])[CH:20]([CH2:21][CH2:22]1)[CH2:19][NH:18][CH2:17]2>>[O:15]=[C:9]1[CH2:8][C:7]2[C:11](=[CH:12][CH:13]=[CH:14][C:6]=2[NH:5][C:3]([CH2:2][N:18]2[CH2:19][CH:20]3[N:23]([C:24]([O:26][C:7]([CH3:11])([CH3:8])[CH3:6])=[O:25])[CH:16]([CH2:22][CH2:21]3)[CH2:17]2)=[O:4])[NH:10]1参加物
3
実験手順
The subtitle compound was prepared from the product of step (i) (0.24 g) and 1,1-dimethyl, 3,8-diazabicyclo[3.2.1]octane-8-carboxylate (0.26 g) by the method of Example 19 step (i) Yield: 0.8 g
出典と根拠
- ORDレコード
- ord-80a832a66c1e4042bdb68bc0941c8276
- 出典データセット
- uspto-grants-2005_11