2-chloro-N-(3-fluoro-2-methylphenyl)acetamide → cis-(3,5-Dimethylpiperazin-1-yl)-N-(2-methyl-3-fluorophenyl)acetamide

反応式

Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[C:7]=1[CH3:13])=[O:4].[CH3:14][C@H:15]1[CH2:20][NH:19][CH2:18][C@@H:17]([CH3:21])[NH:16]1>>[CH3:14][C@H:15]1[NH:16][C@@H:17]([CH3:21])[CH2:18][N:19]([CH2:2][C:3]([NH:5][C:6]2[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[C:7]=2[CH3:13])=[O:4])[CH2:20]1

参加物

反応物 2

HCID 9542492-chloro-N-(3-fluoro-2-methylphenyl)acetamide

HCID 6950261rel-(2R,6S)-2,6-dimethylpiperazine

生成物 1

HCID 69746587cis-(3,5-Dimethylpiperazin-1-yl)-N-(2-methyl-3-fluorophenyl)acetamide

実験手順

The subtitle compound was prepared from the product of Example 36 step (i) (14.5 g) and cis-2,6-dimethylpiperazine (9.0 g) by the method of Example 58 step (i) as cream solid. Yield: 11.48 g

出典と根拠

ORDレコード: ord-89d9a2d4b206406ea519fdeed7c25a0c
出典データセット: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06969713B2

反応ノート

読み込み中…