2-chloro-N-(5-cyano-2-methylphenyl)acetamide → cis-2-[4-(3-Cyanobenzenesulphonyl)-3,5-dimethylpiperazin-1-yl]-n-(5-cyano-2-methylphenyl)acetamide

HRID 1064600ノート

反応式

HRID 1064600 の反応式
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[C:10]([C:12]#[N:13])[CH:9]=[CH:8][C:7]=1[CH3:14])=[O:4].[C:15]([C:17]1[CH:18]=[C:19]([S:23]([N:26]2[C@H:31]([CH3:32])[CH2:30][NH:29][CH2:28][C@@H:27]2[CH3:33])(=[O:25])=[O:24])[CH:20]=[CH:21][CH:22]=1)#[N:16]>>[C:15]([C:17]1[CH:18]=[C:19]([S:23]([N:26]2[C@@H:31]([CH3:32])[CH2:30][N:29]([CH2:2][C:3]([NH:5][C:6]3[CH:11]=[C:10]([C:12]#[N:13])[CH:9]=[CH:8][C:7]=3[CH3:14])=[O:4])[CH2:28][C@H:27]2[CH3:33])(=[O:24])=[O:25])[CH:20]=[CH:21][CH:22]=1)#[N:16]

参加物

3

反応物 2

HCID 222734112-chloro-N-(5-cyano-2-methylphenyl)acetamideHCID 69744750cis-1-(3-Cyanobenzenesulphonyl)-2,6-dimethylpiperazine

生成物 1

HCID 69745774cis-2-[4-(3-Cyanobenzenesulphonyl)-3,5-dimethylpiperazin-1-yl]-n-(5-cyano-2-methylphenyl)acetamide

実験手順

The title compound was prepared from the product of step (i) (0.19 g) and the product from Example 80 step (ii) (0.2 g) by the method of Example 80 step (iii) as a white solid. Yield: 0.25 g

出典と根拠

ORDレコード
ord-e70d5c1c298e4bc79df3685c4756b6e0
出典データセット
uspto-grants-2005_11
特許番号
US06969713B2

反応ノート

読み込み中…