Iodine → 2-iodobenzene-1,3-diol

HRID 1064738ノート

反応式

HRID 1064738 の反応式
[C:1]1([CH:8]=[CH:7][CH:6]=[C:4]([OH:5])[CH:3]=1)[OH:2].[I:9]I.C([O-])(O)=O.[Na+]>O>[I:9][C:3]1[C:1]([OH:2])=[CH:8][CH:7]=[CH:6][C:4]=1[OH:5]

参加物

5

反応物 3

HCID 807IodineHCID 5054ResorcinolHCID 516892Sodium Bicarbonate

生成物 1

HCID 6168332-iodobenzene-1,3-diol収率 78%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Resorcinol (2.75 g, 25 mmol) in 20 mL of water and ice was treated with iodine (6.7 g, 26.4 mmol) and NaHCO3 (2.3 g, 27.4 mmol) in one portion. After stirring for 1 hour, the precipitate was separated by filtration and the filtrate was extracted twice (2×75 mL) with diethyl ether. The organic phase was dried over sodium sulfate and evaporated under reduced pressure. The solid was triturated with 20 ML of chloroform and left at −18° C. for 24 hours. The solid was separated by filtration to provide the title compound (78% yield). 1HNMR (300 MHz, CDCl3) δ 4.85 (s, 1H), 6.30 (m, 2H), 6.95 (m, 1H). MS (CDI) m/z 237 (M+H)+.

後処理

  1. customthe precipitate was separated by filtration
  2. extractionthe filtrate was extracted twice (2×75 mL) with diethyl ether
  3. dry with materialThe organic phase was dried over sodium sulfate
  4. customevaporated under reduced pressure
  5. customThe solid was triturated with 20 ML of chloroform
  6. waitleft at −18° C. for 24 hours
  7. customThe solid was separated by filtration

出典と根拠

ORDレコード
ord-de040ce6123e477ab7fc3b605a4116d5
出典データセット
uspto-grants-2005_11
特許番号
US06969730B2

反応ノート

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