2-Nitro-6-(trifluoromethyl)phenol → 2-Amino-6-(trifluoromethyl)phenol

HRID 1064822ノート

反応式

HRID 1064822 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[C:5]=1[OH:14])([O-])=O>[C].[Pd].C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:11])([F:12])[F:13])[C:5]=1[OH:14]

参加物

4

反応物 1

HCID 9018342-Nitro-6-(trifluoromethyl)phenol

生成物 1

HCID 222727462-Amino-6-(trifluoromethyl)phenol収率 99.5%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

A 10% palladium carbon catalyst (1.0 g) was added to a solution of the resulting nitro compound (2.0 g, 9.65 mmol) in ethanol (60 ml) and the mixture was stirred under hydrogen atmosphere at room temperature for 5 hours. After completion of the reaction, the reaction solution was filtered off through celite and the filtrate was concentrated to provide 1.70 g (yield 99%) of 2-amino-6-trifluoromethylphenol as pale yellow crystals.

後処理

  1. customAfter completion of the reaction
  2. filtrationthe reaction solution was filtered off through celite
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-31ad81e73b97470880c00480371c7a49
出典データセット
uspto-grants-2005_11
特許番号
US06969711B2

反応ノート

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