Acetone → HCID 86737701、化合物

反応式

C[C:2]1[CH:11]=[CH:10][C:5]([C:6](=[O:9])[CH2:7]Br)=[CH:4][CH:3]=1.O.O.[N+:14]([C:17]1[CH:22]=[CH:21][C:20]([O-:23])=[CH:19][CH:18]=1)([O-:16])=[O:15].[Na+].[CH3:25]C(C)=O>>[CH3:25][C:17]1([N+:14]([O-:16])=[O:15])[CH:22]=[CH:21][C:20]([O:23][CH2:7][C:6]([C:5]2[CH:4]=[CH:3][CH:2]=[CH:11][CH:10]=2)=[O:9])=[CH:19][CH2:18]1

参加物

反応物 3

HCID 180Acetone

HCID 692722-Bromo-4'-methylacetophenone

HCID 2735104Sodium 4-nitrophenolate dihydrate

生成物 1

HCID 86737701HCID 86737701、化合物収率 78.9%

実験手順

4-Methylphenacyl chloride (XVI: X=Cl) (37.8 g, 0.224 mole) and sodium 4-nitrophenolate (XI) (38.6 g, 0.24 mole) were added to acetone (300 ml), and the mixture was heated under reflux for 10 hours. Thereafter, the reaction mixture was treated in the same manner as in Example 29 to obtain 47.9 g of 4-methyl-α-(4-nitrophenoxy)acetophenone (XII) (yield, 78.9 %).

後処理

temperaturethe mixture was heated
temperatureunder reflux for 10 hours
additionThereafter, the reaction mixture was treated in the same manner as in Example 29

出典と根拠

ORDレコード: ord-789895fcd44444728688329ad8c62a00
出典データセット: uspto-grants-1982_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04328166

反応ノート

読み込み中…

参加物