Hydrochloric Acid → HCID 13891603、化合物

HRID 1065059ノート

反応式

HRID 1065059 の反応式
[CH3:1][C:2]1[C:7]2=[CH:8][CH:9]=[CH:10][C:11]([C:12]([O:14][C@H:15]3[C@H:27]([O:28][C@H:29]4[O:34][C@H:33]([CH3:35])[C@H:32]([OH:36])[C@H:31]([OH:37])[C@H:30]4[NH:38][CH3:39])[C:26]4=[CH:25][C:24]#[C:23][C@H:21]5[O:22][C@@:20]5([C@@H:40]5[O:45][C:43](=[O:44])[O:42][CH2:41]5)[C:19]#[C:18][C:17]4=[CH:16]3)=[O:13])=[C:6]2[CH:5]=[C:4]([O:46][CH3:47])[CH:3]=1.Cl.C[OH:50]>>[CH3:35][C@H:33]1[O:34][C@H:29]([O:28][C@H:27]2[C@H:15]([O:14][C:12]([C:11]3[C:6]4[C:7](=[C:2]([CH3:1])[CH:3]=[C:4]([O:46][CH3:47])[CH:5]=4)[CH:8]=[CH:9][C:10]=3[OH:50])=[O:13])[CH:16]=[C:17]3[C:18]#[C:19][C@:20]4([CH:40]5[O:45][C:43](=[O:44])[O:42][CH2:41]5)[O:22][C@@H:21]4[C:23]#[C:24][CH:25]=[C:26]23)[C@H:30]([NH:38][CH3:39])[C@@H:31]([OH:37])[C@H:32]1[OH:36]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 44581473[(4S,6R,9E,11R,12R)-11-[(2R,3R,4R,5R,6R)-4,5-dihydroxy-6-methyl-3-(methylamino)oxan-2-yl]oxy-4-[(4R)-2-oxo-1,3-dioxolan-4-yl]-5-oxatricyclo[8.3.0.04,6]trideca-1(13),9-dien-2,7-diyn-12-yl] 7-methoxy-5-methylnaphthalene-1-carboxylate

生成物 1

HCID 13891603HCID 13891603、化合物

実験手順

Into 1.5 l of a 95% methanol solution was suspended 16 g of neocarzinostatin powder. After adjusting the pH of the suspension with 1 N hydrochloric acid to pH 2.0, the suspension was stirred for 2 hours and then subjected to centrifugal separation. The supernatant was then concentrated and dried to 920 mg of crude powder of the NCS-C substance. The crude powder was subjected to Sephadex LH-20 chromatography in the same manner as in Example 3. The NCS-C substance was obtained in a powder form (yield: 105 mg).

後処理

  1. customsubjected to centrifugal separation
  2. concentrationThe supernatant was then concentrated
  3. dry with materialdried to 920 mg of crude powder of the NCS-C substance

出典と根拠

ORDレコード
ord-2a7bca97818c40daacabb3d6fe851fc0
出典データセット
uspto-grants-1982_05
特許番号
US04328212

反応ノート

読み込み中…