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Benzene → 2-Fluoro-N-phenylacetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzene | HCID 241 | — |
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | 2-Fluoroaniline | HCID 9584 | — |
| 生成物 | 2-Fluoro-N-phenylacetamide | HCID 9504 | — |
反応手順
In benzene, 2-fluoroaniline was acetylated with acetic anhydride to obtain 2-fluoroacetanilide. This 2-fluoroacetanilide was held in glacial acetic acid at 43°-52° C. and an equivalent of chlorine gas was introduced, whereby 2-fluoro-4-chloroacetanilide was obtained. This product was deacetylated with hydrochloric acid and neutralized with sodium hydroxide to recover 2-fluoro-4-chloroaniline as an oil boiling at 64°-65° C./0.25 mmHg.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04328367 |
| 出典データセット | uspto-grants-1982_05 |
| ORD ID | ord-65735f6d54f24ea4b80fbe379973d5fc |
| 出典メモ | uspto-grants-1982_05 |