Potassium Hydroxide → N-(4-amino-5-chloro-2-methoxyphenyl)-4-benzylpiperazine-1-carboxamide

HRID 1065231

反応式

HRID 1065231 の反応式
C([NH:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([NH:12][C:13]([N:15]2[CH2:20][CH2:19][N:18]([CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:17][CH2:16]2)=[O:14])=[C:7]([O:28][CH3:29])[CH:6]=1)(=O)C.[OH-].[K+]>C(O)C>[NH2:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([NH:12][C:13]([N:15]2[CH2:16][CH2:17][N:18]([CH2:21][C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:19][CH2:20]2)=[O:14])=[C:7]([O:28][CH3:29])[CH:6]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 20538750N-(4-acetylamino-5-chloro-2-methoxyphenyl)-4-benzylpiperazine-1-carboxamide

生成物 1

HCID 20538744N-(4-amino-5-chloro-2-methoxyphenyl)-4-benzylpiperazine-1-carboxamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of N-(4-acetylamino-5-chloro-2-methoxyphenyl)-4-benzylpiperazine-1-carboxamide (e9) (1.4 g) in ethanol (20 ml) was refluxed for 1 hour with an aqueous (4 ml) solution of potassium hydroxide (0.6 g). The solvent was removed by evaporation and the residue extracted with ethyl acetate. Chromatography of the solution (on alumina with 5% water, in chloroform) followed by evaporation of the solvent yielded N-(4-amino-5-chloro-2-methoxyphenyl)-4-benzylpiperazine-1- carboxamide (e10).

後処理

  1. customThe solvent was removed by evaporation
  2. extractionthe residue extracted with ethyl acetate
  3. customChromatography of the solution (on alumina with 5% water, in chloroform) followed by evaporation of the solvent

出典と根拠

ORDレコード
ord-2fbcd36538774dfb9c828c61312512f1
出典データセット
uspto-grants-1982_05
特許番号
US04329344

関連ノート

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