Hydrochloric Acid → 1-(4-Fluorophenyl)-4-oxocyclohexanecarboxylic acid

HRID 1065270ノート

反応式

HRID 1065270 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:18]([OH:20])=[O:19])[CH2:17][CH2:16][C:11]3(OCC[O:12]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl>C(O)(=O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:18]([OH:20])=[O:19])[CH2:9][CH2:10][C:11](=[O:12])[CH2:16][CH2:17]2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 122302461,4-Dioxaspiro[4.5]decane-8-carboxylic acid, 8-(4-fluorophenyl)-

生成物 1

HCID 219553321-(4-Fluorophenyl)-4-oxocyclohexanecarboxylic acid収率 50%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 40 parts of 8-(4-fluorophenyl)-1,4-dioxaspiro[4,5]decane-8-carboxylic acid, 100 parts of a hydrochloric acid solution 6 N and 100 parts of acetic acid is started and refluxed overnight. The reaction mixture is cooled and the product is extracted with trichloromethane. The extract is washed three times with water, dried, filtered and evaporated, yielding 17 parts (50%) of 1-(4-fluorophenyl)-4-oxocyclohexanecarboxylic acid as a residue.

後処理

  1. temperaturerefluxed overnight
  2. temperatureThe reaction mixture is cooled
  3. extractionthe product is extracted with trichloromethane
  4. washThe extract is washed three times with water
  5. customdried
  6. filtrationfiltered
  7. customevaporated

出典と根拠

ORDレコード
ord-308570129b6a45b1ac6ba068a10387fd
出典データセット
uspto-grants-1982_05
特許番号
US04329353

反応ノート

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