6-Hydroxy-3,4-dihydro-2(1H)-quinolinone → 6-(4-Phenylmercapto-butoxy)-3,4-dihydro-carbostyril

反応式

[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[CH2:6][CH2:5]2.[C:13]1([S:19][CH2:20][CH2:21][CH2:22][CH2:23]Br)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:13]1([S:19][CH2:20][CH2:21][CH2:22][CH2:23][O:1][C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][CH:11]=2)[NH:8][C:7](=[O:12])[CH2:6][CH2:5]3)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

反応物 2

HCID 27740406-Hydroxy-3,4-dihydro-2(1H)-quinolinone

HCID 111841484-Phenylmercapto-butylbromide

生成物 1

HCID 248459066-(4-Phenylmercapto-butoxy)-3,4-dihydro-carbostyril

実験手順

Prepared analogous to Example 4 from 6-hydroxy-3,4-dihydro-carbostyril and 4-(phenylmercapto)-butyl bromide (b.p. 96°-103° C. at 0.02 mm Hg; prepared from thiophenol and 1.4-dibromo butane).

出典と根拠

ORDレコード: ord-ee6c1beeee7b48b29b730a9ee0424da7
出典データセット: uspto-grants-1982_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04329347

反応ノート

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