Thiophenol → 6-(2-Hydroxy-3-phenylmercapto-propoxy)-3,4-dihydro-carbostyril

反応式

[C:1]1([SH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[O-].[K+].[O:11]1[CH2:26][CH:12]1[CH2:13][O:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[NH:21][C:20](=[O:25])[CH2:19][CH2:18]2>CO>[OH:11][CH:12]([CH2:26][S:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH2:13][O:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[NH:21][C:20](=[O:25])[CH2:19][CH2:18]2

参加物

実験手順

4.11 gm (0.04 mol) of thiophenol were added to a suspension of 2.10 gm (0.03 mol) of potassium methylate in 40 ml of methanol, whereby a clear solution was obtained. Then, 4.38 gm of 6-(2,3-epoxy-propoxy)-3,4-dihydro-carbostyril (m.p. 125°-128° C.) were added while stirring, which also dissolved, accompanied by slight generation of heat. After 5 minutes the separation of a white crystal slurry started. After standing overnight, the crystals were suction-filtered off and recrystallized from a little methanol. White crystals with a melting point of 148°-149° C. were obtained.