Hydrogen Peroxide → 5-(4-Phenylsulfinyl-butoxy)-carbostyril

HRID 1065371ノート

反応式

HRID 1065371 の反応式
[OH:1]O.[C:3]1([S:9][CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:24]=[CH:23][CH:22]=[C:21]3[C:16]=2[CH:17]=[CH:18][C:19](=[O:25])[NH:20]3)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C(O)(=O)C.O>[C:3]1([S:9]([CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:24]=[CH:23][CH:22]=[C:21]3[C:16]=2[CH:17]=[CH:18][C:19](=[O:25])[NH:20]3)=[O:1])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

参加物

5

反応物 2

HCID 784Hydrogen PeroxideHCID 538402795-(4-Phenylmercapto-butoxy)-carbostyril

生成物 1

HCID 205401285-(4-Phenylsulfinyl-butoxy)-carbostyril

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

実験手順

0.165 ml of 30% hydrogen peroxide, dissolved in 8 ml of glacial acetic acid, were added to 0.56 gm of 5-(4-phenylmercapto-butoxy)-carbostyril. The mixture was diluted with water and extracted twice with chloroform. The chloroform extract was washed with dilute sodium carbonate solution and with water, dried over magnesium sulfate and evaporated. The residue was admixed with ethyl acetate, yielding colorless crystals with a melting point of 155°-157° C.

後処理

  1. extractionextracted twice with chloroform
  2. extractionThe chloroform extract
  3. washwas washed with dilute sodium carbonate solution and with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated
  6. customyielding colorless crystals with a melting point of 155°-157° C.

出典と根拠

ORDレコード
ord-6e5d00fc9ec0487eaf7db48c123f4ebf
出典データセット
uspto-grants-1982_05
特許番号
US04329347

反応ノート

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