Morpholine → HCID 70550960、化合物

HRID 1065480ノート

反応式

HRID 1065480 の反応式
[N+:1]([C:4]1[CH:19]=[CH:18][C:7]([CH:8]=[N:9][NH:10][C:11]2[N:12]=[N:13][C:14](Cl)=[CH:15][CH:16]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>CN(C)P(=O)(N(C)C)N(C)C>[N+:1]([C:4]1[CH:19]=[CH:18][C:7]([CH:8]=[N:9][NH:10][C:11]2[N:12]=[N:13][C:14]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[CH:15][CH:16]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 8083MorpholineHCID 593142HCID 593142、化合物

生成物 1

HCID 70550960HCID 70550960、化合物収率 85.3%

試薬・触媒・溶媒 1

HCID 12679Hexamethylphosphoramide溶媒

実験手順

The mixture of 5.55 g (20 mmoles) of 4-nitrobenzylidene-(6-chloro-3-pyridazinyl)-hydrazine [prepared by the process described in Step a:], 7.66 g (88 mmoles) of morpholine and 5.5 ml of hexamethylphosphoric cid triamide is heated at 150° C. for 24 hours. After cooling, the mixture is triturated with 56 ml of water, the precipitate is filtered, washed with cold ethanol and dried to give 5.6 g (85%) of the named compound; m.p. 245° C. (with decomposition).

後処理

  1. customprepared by the process
  2. temperatureAfter cooling
  3. customthe mixture is triturated with 56 ml of water
  4. filtrationthe precipitate is filtered
  5. washwashed with cold ethanol
  6. customdried

出典と根拠

ORDレコード
ord-50e66ff8481545c1857329f3e3d3d8fc
出典データセット
uspto-grants-1982_05
特許番号
US04329457

反応ノート

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