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Acetic Acid → 2-[1-(p-Chlorophenyl)-1H-1,2,4-triazol-5-yl]pyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1) | HCID 71600 | — |
| 反応物 | N-[(Dimethylamino)methylene]pyrazine-2-carboxamide | HCID 16727655 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2-[1-(p-Chlorophenyl)-1H-1,2,4-triazol-5-yl]pyrazine | HCID 12850296 | — |
反応手順
To a solution of 12.1 g. of 4-chlorophenylhydrazine hydrochloride in a mixture of 13.5 ml. of 5 N sodium hydroxide, 100 ml. of 30% aqueous acetic acid and 50 ml. of p-dioxane is added 10.0 g. of N-(dimethylaminomethylene pyrazinecarboxamide. The procedure of Example 2 is then followed giving 3.8 g. of the desired product as tan crystals, mp. 129°-131° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04329463 |
| 出典データセット | uspto-grants-1982_05 |
| ORD ID | ord-36441536f6974381807310e7cf6117b9 |
| 出典メモ | uspto-grants-1982_05 |