Hydrochloric Acid → 5-Chlorouracil
反応式
Cl.[Cl:2][C:3]1(C(OC)=O)[CH:8](O)[NH:7][C:6](=[O:10])[NH:5][C:4]1=[O:11]>>[Cl:2][C:3]1[C:4](=[O:11])[NH:5][C:6](=[O:10])[NH:7][CH:8]=1参加物
3
実験手順
In 15 ml. of concentrated hydrochloric acid, 345 mg. of methyl 5-chloro-6-hydroxy-1,2,3,4,5,6-hexahydro-2,4-dioxopyrimidine-5-carboxylate is heated under reflux for 15 hours. The reaction mixture is cooled with ice, whereupon 92 mg. of 5-chlorouracil is obtained as colorless prisms.
後処理
- temperatureunder reflux for 15 hours
- temperatureThe reaction mixture is cooled with ice, whereupon 92 mg
出典と根拠
- ORDレコード
- ord-38903b307ce349258b3a3861a9e96bb1
- 出典データセット
- uspto-grants-1982_05
- 特許番号
- US04329460
反応ノート
読み込み中…