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4-Acetylbenzoic Acid → 4-[3E-(3-Thiophen-2-yl-phenyl)-acryloyl]-benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Acetylbenzoic Acid | HCID 11470 | — |
| 反応物 | 3-(2-Thienyl)benzaldehyde | HCID 4281100 | — |
| 生成物 | 4-[3E-(3-Thiophen-2-yl-phenyl)-acryloyl]-benzoic acid | HCID 10149901 | 71% |
反応手順
The title compound was prepared by condensing 3-(thiophen-2-yl)-benzaldehyde (Ex-42A) and 4-acetylbenzoic acid in a similar manner as described in Ex-3. Yellow solid, mp 238° C. (dec), 71% yield. 1H-NMR (DMSO-D6) δ 13.40 (bs, 1H), 8.29 (d, J=8 Hz, 2H), 8.22 (s, 1H), 8.13 (d, J=8 Hz, 2H), 8.04 (s, 1H), 7.87 (s, 1H), 7.83 (d, J=8 Hz, 1H), 7.73 (d, J=9 Hz, 1H), 7.69 (d, J=4 Hz, 1H), 7.63 (d, J=5 Hz, 1H), 7.52 (t, J=8 Hz, 1H), 7,20 (dd, J=4, 5 Hz, 1H). HRMS m/z=calc. 335.0742, found 335.0749.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07094801B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-12ec378e0f82417390911f19266aae37 |
| 出典メモ | uspto-grants-2006_08 |