Phenyl isocyanate → N-(4-pyridazinyl)-N'-phenylurea

HRID 1065941

反応式

HRID 1065941 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[N:4][CH:3]=1.[C:8]1([N:14]=[C:15]=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>CC(C)=O>[N:5]1[CH:6]=[CH:7][C:2]([NH:1][C:15]([NH:14][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:16])=[CH:3][N:4]=1

参加物

4

反応物 2

HCID 7672Phenyl isocyanateHCID 2984924-Aminopyridazine

生成物 1

HCID 12893792N-(4-pyridazinyl)-N'-phenylurea

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

200 mg. of 4-aminopyridazine was suspended in 50 ml. of acetone. To the resulting suspension, 1.2 times the amount of phenyl isocyanate theoretically calculated was added and the mixture then reacted at room temperature overnight. The crystals formed were taken out by filtration. By recrystallization from an excess of methanol, N-(4-pyridazinyl)-N'-phenylurea was obtained (yield, greater than 80%); melting point higher than 250° C.

後処理

  1. customthe mixture then reacted at room temperature overnight
  2. customThe crystals formed
  3. filtrationwere taken out by filtration
  4. customBy recrystallization from an excess of methanol

出典と根拠

ORDレコード
ord-b643778aea364656bc2dd9c46168b1ef
出典データセット
uspto-grants-1982_05
特許番号
US04331807

関連ノート

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