Hydrochloric Acid → HCID 20573874、化合物

HRID 1065961ノート

反応式

HRID 1065961 の反応式
C[O:2][C:3]1[CH:10]=[C:9](OC)[C:6]([CH:7]=O)=[C:5]([OH:13])[CH:4]=1.[CH3:14][C:15]([C:17]1[CH:22]=[CH:21][C:20]([O:23]C)=[CH:19][CH:18]=1)=[O:16].[ClH:25]>CCOCC>[CH:18]1[C:17]([C:15]2[CH:14]=[CH:7][C:6]3[C:5]([OH:13])=[CH:4][C:3]([OH:2])=[CH:10][C:9]=3[O+:16]=2)=[CH:22][CH:21]=[C:20]([OH:23])[CH:19]=1.[Cl-:25].[Cl-:25]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 74764'-MethoxyacetophenoneHCID 697254,6-Dimethoxysalicylaldehyde

生成物 1

HCID 20573874HCID 20573874、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

One method consists, for example, in preparing, in a first step, trimethylapigenidin by condensation of commercially available 4,6-dimethoxy-2-hydroxybenzaldehyde with commercially available 4-methoxyacetophenone at 0° C. in anhydrous ether medium, and saturation with anhydrous HCl in order to obtain, after filtration, an orange-red precipitate of trimethylapigenidin. In a second step, in hydrolysing the trimethylapigenidin obtained in the preceding step to apigenidin chloride, the reaction being carried out in an HI and phenol and AgCl medium in solution in methanol. Such a method of synthesis is described by R. Robinson and A. Robertson in J., Chem., Soc. 1951-(1926) and 2196-(1927).

後処理

  1. customto obtain
  2. filtrationafter filtration

出典と根拠

ORDレコード
ord-950eaab79849496da2cb9d7fe7039fdb
出典データセット
uspto-grants-2001_06
特許番号
US06241785B1

反応ノート

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