Hydrochloric Acid → 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, hydrochloride, (S)-

HRID 1066011ノート

反応式

HRID 1066011 の反応式
[ClH:1].[CH3:2][C:3]([NH:6][CH2:7][C@H:8]([OH:22])[CH2:9][O:10][C:11]1[C:12]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)=[N:13][S:14][N:15]=1)([CH3:5])[CH3:4]>C(O)(C)C>[ClH:1].[CH3:5][C:3]([NH:6][CH2:7][C@H:8]([OH:22])[CH2:9][O:10][C:11]1[C:12]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)=[N:13][S:14][N:15]=1)([CH3:2])[CH3:4]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 33624Timolol

生成物 1

HCID 1552082-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, hydrochloride, (S)-収率 91%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒2 回

実験手順

0.8 ml of a 7M HCl solution in isopropanol was added dropwise to a magnetically stirred solution of timolol (1.4 g) in isopropanol (30 ml). The solution was stirred for 30 minutes. The reaction mixture was freed of the solvent at reduced pressure. 1.47 g of pure product was obtained (yield 91%).

出典と根拠

ORDレコード
ord-4441b34afb6240a7bee27d9b58d30fb9
出典データセット
uspto-grants-2001_06
特許番号
US06242432B1

反応ノート

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