Phosgene → HCID 178422564、化合物

反応式

NC1C=C(C)C=CC=1S(N)(=O)=O.C(N=C=S)(C)C.[NH2:19][C:20]1[CH:25]=[C:24]([CH3:26])[CH:23]=[CH:22][C:21]=1[S:27]([NH:30][C:31]([NH:33][CH:34]([CH3:36])[CH3:35])=S)(=[O:29])=[O:28].C(Cl)(Cl)=O>>[CH:34]([NH:33][C:31]1[NH:19][C:20]2[CH:25]=[C:24]([CH3:26])[CH:23]=[CH:22][C:21]=2[S:27](=[O:29])(=[O:28])[N:30]=1)([CH3:36])[CH3:35]

参加物

反応物 4

HCID 6371Phosgene

HCID 75263Isopropyl Isothiocyanate

HCID 114365382-Amino-4-methylbenzenesulfonamide

HCID 21197735N-(2-amino-4-methylbenzenesulfonyl)-N'-isopropylthiourea

生成物 1

HCID 178422564HCID 178422564、化合物

実験手順

Starting from 2-amino-4-methylbenzenesulfonamide and isopropyl isothiocyanate, and following a procedure analogous to the one described in Example 4a, N-(2-amino-4-methylbenzenesulfonyl)-N′-isopropylthiourea was prepared, m.p. 137-139° C. Subsequent ring closure with phosgene by a procedure analogous to the one described in Example 4b gave the title compound; m.p. 309-311° C.