5-Methyl-2-hexylamine → HCID 178443973、化合物

HRID 1066119

反応式

HRID 1066119 の反応式
Cl[C:2]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([Cl:12])=[CH:11][C:5]=2[S:4](=[O:14])(=[O:13])[N:3]=1.[CH3:15][CH:16]([NH2:22])[CH2:17][CH2:18][CH:19]([CH3:21])[CH3:20]>>[Cl:12][C:10]1[CH:9]=[CH:8][C:6]2[NH:7][C:2]([NH:22][CH:16]([CH3:15])[CH2:17][CH2:18][CH:19]([CH3:21])[CH3:20])=[N:3][S:4](=[O:14])(=[O:13])[C:5]=2[CH:11]=1

参加物

3

反応物 2

HCID 342045-Methyl-2-hexylamineHCID 12700105HCID 12700105、化合物

生成物 1

HCID 178443973HCID 178443973、化合物

実験手順

Starting from 3,7-dichloro-4H-1,2,4-benzothiadiazine 1,1-dioxide (300 mg; 1.19 mmol) and 1,4-dimethylpentylamine (1.0 g; 8.68 mmol) with the use of same procedure as in example 21 210 mg (53.5%) of the title compound was prepared; m.p. >220° C.; 1H-NMR (DMSO-d6) ppm; 10.4 (s, 1H, NH), 7.7 (d, 1H, H-8), 7.6 (dd, 1H, H-5), 7.25 (d, 1H, H-7), 7.1 (br, 1H, NH), 3.88 (q, 1H, CH2), 1.55 (m, 3H), 1.21 (m, 2H), 1.1 (d, 3H, CH3), 0.9 (d, 6H, 2×CH3); MS:EI/70eV: 330 (M+), 258, 231, 190, 126, 69, 55, 44. Analysis: C10H12ClN3O2S requires C, 50.98; H, 6.11; N, 12.74; (found C, 51.14; H, 6.43; N, 12.64)

出典と根拠

ORDレコード
ord-8f145ce8ffb745e1b6c8e2b024192af0
出典データセット
uspto-grants-2001_06
特許番号
US06242443B1

関連ノート

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