Formic Acid → HCID 178523417、化合物
反応式
[CH:1]([OH:3])=O.C(OC(=O)C)(=O)C.O.[NH2:12][CH2:13][CH2:14][NH:15][C:16]1[NH:21][C:20]2[CH:22]=[CH:23][C:24]([Cl:26])=[CH:25][C:19]=2[S:18](=[O:28])(=[O:27])[N:17]=1>O>[Cl:26][C:24]1[CH:23]=[CH:22][C:20]2[NH:21][C:16]([NH:15][CH2:14][CH2:13][NH:12][CH:1]=[O:3])=[N:17][S:18](=[O:28])(=[O:27])[C:19]=2[CH:25]=1参加物
5
反応条件
- 温度
- 50 °C
実験手順
A mixture of formic acid (1 mL) and acetic anhydride (2 mL) was heated at 50° C. for 20 min. After cooling at room temperature, 3-(2-aminoethyl)amino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxide monohydrate (0.5 g) was added, and the reaction mixture was stirred for 2 h, then supplemented with water (20 mL) and stirred for 20 min. The precipitate was collected by filtration, washed with water and dried (yield: 0.3 g); m.p. 245-247° C.