N-Methylethylamine → HCID 21197892、化合物

反応式

Cl[C:2]1[NH:7][C:6]2[CH:8]=[C:9]([Cl:12])[CH:10]=[CH:11][C:5]=2[S:4](=[O:14])(=[O:13])[N:3]=1.[CH2:15]([NH:17][CH3:18])[CH3:16]>>[Cl:12][C:9]1[CH:10]=[CH:11][C:5]2[S:4](=[O:14])(=[O:13])[N:3]=[C:2]([N:17]([CH2:15][CH3:16])[CH3:18])[NH:7][C:6]=2[CH:8]=1

参加物

反応物 2

HCID 12219N-Methylethylamine

HCID 211978252H-1,2,4-Benzothiadiazine, 3,6-dichloro-, 1,1-dioxide

生成物 1

HCID 21197892HCID 21197892、化合物

実験手順

Starting from 3,6-dichloro-4H-1,2,4-benzothiadiazine 1,1-dioxide (500 mg; 1.99 mmol) and N-ethyl-N-methylamine (500 mg; 8.47 mmol) and with the use of same procedure as in example 21 200 mg (36.7%) of the title compound was prepared; m.p. >220° C.; 1H-NMR (DMSO-d6) ppm; 10.35 (s, 1H, NH), 7.65 (d, 1H, H-8), 7.58 (dd, 1H, H-5), 7.3 (d, 1H, H-7), 3.5 (q, 2H, CH2), 3.11 (s, 3H, CH3), 1.14 (t, 3H, CH3). Analysis: C10H12ClN3O2S requires C, 43.88; H, 4.42; N, 15.35; (found C, 43.78; H, 4.51; N, 15.24).

出典と根拠

ORDレコード: ord-5c8f441f82e640a0970fd5ede7744721
出典データセット: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06242443B1

反応ノート

読み込み中…

参加物